Сучасні підходи до фармакологічної корекції метаболічних зрушень при цукровому діабеті типу 2

Abstract

Проведено аналіз і систематизацію даних літератури щодо фармакологічної корекції метаболічних порушень при цукровому діабеті типу 2. Використано методи інформаційного пошуку, аналізу даних літератури щодо дослідження лікарських рослин з гіпоглікемічною дією. Розглянуто лікарські рослини та природні амінокислоти, які володіють гіпоглікемічною дією та можуть використовуватись з лікувально-профілактичною метою у хворих з цукровим діабетом типу 2. Встановлено, що біологічно активні компоненти лікарських рослин мoжyть впливати на aктивнicть ключoвиx фepмeнтiв oбмiнy вyглeвoдiв, тpaнcпopт глюкoзи тa фyнкцiї peцeптopa дo iнcyлiнy, пopyшeння якиx вiдiгpaють вaжливy poль в пaтoгeнeзi цукрового діабету.

Diabetes mellitus is caused by one of the largest medical and social problems in Ukraine, because it causes a high risk of invasive disease. According to the WHO data, the number of patients is rising and people of varying age groups become ill, which causes an increase in the incidence of 3 to 4 pauses and the overall life expectancy of 20-30%. Pathogenesis of diabetes mellitus and enclosure, require the extraction of drugs for prophylaxis and treatment with late pharmacological effects. One of these is a herbal remedy. Analysis and systematization of the literature on metabolitotropic effects and substantiation of the use of new goat's-rue, blueberry and taurine phytocompositions for the correction of metabolic changes in diabetes type 2 were carried out. The methods of information search, analysis of literature on the medicinal plants with hypoglycemic action were used. The literary resources on pharmacological correction of metabolic changes in diabetes type 2 deal with natural herbs and amino acids that possess hypoglycemic action and can be used with therapeutic and prophylactic measure in patients with type 2 diabetes. In type 2 diabetes mellitus significant anticytolytic, detoxifying and antioxidant properties of phytocompositions were confirmed. It is known that in hyperglycemia and insulin resistance that occur at type 2 diabetes mellitus end products of glycosylation and glucose autooxidation are formed, which is accompanied by the activation of lipid peroxidation and the formation of a large number of free radicals. It is known that one of the basic mechanisms for the development of insulin resistance, diabetes mellitus and specific diabetic angiopathies is oxidative stress. One of the major pathogenetic factors in the development and course of type 2 diabetes mellitus is metabolic syndrome. It has been established that correction using both investigated phytocompositions and reference phytopreparation with different efficiency prevented the development of metabolic changes in metabolic syndrome. Biologically active components of medicinal plants, may show hypoglycemic effect which will influence the activity of the enzymes, glucose transcription and the function of the peptide to the incyline, the processes which play an important role in the pathogenesis of diabetes.